That's exactly what former Real World: Boston cast member and current Ashland County District Attorney, Sean Duffy (no relation to the ARWDC ally and all-around good guy of the same name) is doing in Wisconin against House Appropriations Chairman, Congressman Dave Obey. Here's a little bit from the article that seems to capture the incredible substance and depth behind Duffy's candidacy:
Duffy is actually married to another former Real World cast member so it appears as if the recipe for post-reality TV relevance seems to lie in keeping with your own kind (other reality TV stars) and moving to Wisconsin to become a Conservative Republican. Obviously, scientific evidence would probably support the notion that Duffy's offspring are likely to eventually follow in daddy's footsteps and become Real Worlders.
(Hat tip on this on to WAOW-TV's Katie Rosenberg for the intel on this one!)